2. Neurological Disease

Neurological Disease

Neurological Disease

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A range of neurological disorders, including epilepsy and dystonia, may involve dysfunctional intracortical inhibition, and may respond to treatments that modify it. Parkinson’s is a neurodegenerative disease characterized by increased activity of GABA in basal ganglia and the loss of dopamine in nigrostriatum, associated with rigidity, resting tremor, gait with accelerating steps, and fixed inexpressive face. Neurological deficits, along with neuromuscular involvement, are characteristic of mitochondrial disease, and these symptoms can have a dramatic impact on patient quality of life. Neurological features may be manifold, ranging from neural deafness, ataxia, peripheral neuropathy, migraine, seizures, stroke‐like episodes and dementia and depend on the part of the nervous system affected.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-P1528
    Autocamtide 2, amide 99.47%
    Autocamtide 2, amide is a substrate (100 μM final concentration) for CaMK family assays.
    Autocamtide 2, amide
  • HY-P1574
    [Arg8]-Vasotocin 113-80-4 98%
    [Arg8]-Vasotocin is a vertebrate neurohypophyseal peptide of the vasopressin/oxytocin hormone family.
    [Arg8]-Vasotocin
  • HY-P1578
    Galanin (1-16), mouse, porcine, rat 125118-77-6 98%
    Galanin (1-16), mouse, porcine, rat is an agonist of the hippocampal galanin receptor, with a Kd of 3 nM.
    Galanin (1-16), mouse, porcine, rat
  • HY-P1596
    Gluten Exorphin C 142479-62-7 99.86%
    Gluten exorphin C is an opioid peptide derived from wheat gluten. Its IC50 values are 40 μM and 13.5 μM for μ opioid and δ opioid activities in the GPI and MVD assays, respectively.
    Gluten Exorphin C
  • HY-P1738
    [Sar9] Substance P 77128-75-7 98.14%
    [Sar9] Substance P is a potent and selective neurokinin (NK)-1 receptor agonist.
    [Sar9] Substance P
  • HY-P1739
    ACTH (34-39) 69454-10-0 99.88%
    ACTH (34-39) is an adrenocorticotropic hormone fragment. ACTH (34-39) can be used in the study of stress-related sleep disorders.
    ACTH (34-39)
  • HY-P1821
    Myelin Basic Protein 126768-94-3 98.98%
    Myelin Basic Protein (MHP4-14), a synthetic peptide comprising residues 4-14 of myelin basic protein, is a very selective PKC substrate (Km=7 μM). Myelin Basic Protein is not phosphorylated by cyclic AMP-dependent protein kinase, casein kinases I and II, Ca2+/calmodulin-dependent protein kinase II, or phosphorylase kinase, and can be routinely used for the assay of protein kinase C with low background in the crude tissue extracts.
    Myelin Basic Protein
  • HY-P1850
    β-Amyloid (1-20) 186319-68-6 99.67%
    β-Amyloid (1-20) consists of amino acids 1 to 20 of beta amyloid protein.
    β-Amyloid (1-20)
  • HY-P1896
    Hsp70-derived octapeptide 736171-62-3 98.01%
    Hsp70-derived octapeptide is a conserved octapeptide of the C-terminal end of Hsp70, which physically interacts with tetratricopeptide repeat (TPR) motifs.
    Hsp70-derived octapeptide
  • HY-P1904
    Phe-Met-Arg-Phe Like Peptide, Snail Helix aspersa 98495-35-3 99.70%
    Phe-Met-Arg-Phe Like Peptide, Snail Helix aspersa is a FMRF-like peptide from visceral and somatic muscles of the snail Helix aspersa. FMRF (Phe-Met-Arg-Phe) is a neuropeptide peptide consisting of 4 amino acid residues.
    Phe-Met-Arg-Phe Like Peptide, Snail Helix aspersa
  • HY-P2000
    Septide 79775-19-2 98.97%
    Septide ((Pyr6,Pro9)-Substance P) is a potent NK1 receptor agonist with a Kd value of 0.55 nM.
    Septide
  • HY-P2155
    BigLEN(rat) 369377-66-2 98.98%
    BigLEN(rat) is a potent GPR171 agonist with an EC50 of 1.6 nM.
    BigLEN(rat)
  • HY-P2243
    D-JBD19 954134-42-0 99.84%
    D-JBD19 is an impermeable peptide that serves as an inactive control for the JNK inhibitor D-JNKI1 (HY-P0069). D-JNKI1 has neuroprotective effects.
    D-JBD19
  • HY-P2275
    Peptide5 916977-43-0 98.39%
    Peptide5, a connexin 43 mimetic peptide, reduce animals swelling, astrogliosis, and neuronal cell death after spinal cord injury
    Peptide5
  • HY-P2497
    Exendin (5-39) 196109-27-0 99.81%
    Exendin (5-39) is a potent glucagon-like peptide 1 (GLP-1) receptor antagonist. Exendin (5-39) improves memory impairment in β-amyloid protein-treated rats.
    Exendin (5-39)
  • HY-P2785
    Phrixotoxin-1 221872-97-5 98%
    Phrixotoxin 1, from the venom of the theraphosid spider Phrixotrichus auratus, is a specific peptide inhibitor of Kv4 potassium channel.
    Phrixotoxin-1
  • HY-P2867
    Phosphodiesterase II, Bovine Spleen 9068-54-6
    Phosphodiesterase II (EC 3.1.16.1), namely phosphodiesterase 2, is mainly involved in the hydrolysis of the important second messengers cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP), and is often used in biochemical research. Phosphodiesterase II is expressed in a variety of tissues, such as the adrenal medulla, brain, heart, platelets, macrophages and endothelial cells, and is involved in the regulation of many different intracellular processes.
    Phosphodiesterase II, Bovine Spleen
  • HY-P3037
    Imperatoxin A 172451-37-5 98%
    Imperatoxin A, a peptide toxin derived from the venom of the African scorpion Pandinus imperator, activator of Ca2+-release channels/ryanodine receptors (RyRs) enhances the influx of Ca2+ from the sarcoplasmatic reticulum into the cell.
    Imperatoxin A
  • HY-P3069
    γ-Neuropeptide (rabbit) 114882-65-4 99.99%
    γ-Neuropeptide (rabbit) can be isolated from rabbit intestine. γ-Neuropeptide is an endogenous neurokinin peptide that acts as a neurokinin 2 (NK2) receptor agonist. γ-Neuropeptide mediates hypothalamic-pituitary-adrenal (HPA) axis, as well as reproductive hormone release.
    γ-Neuropeptide (rabbit)
  • HY-P3242
    Mad1 (6-21) 880150-82-3 98.02%
    Mad1 (6-21) is the 6-21 fragment of Mad1 protein. Mad1 (6-21) binds to mammalian Sin3A PAH2 with a Kd of ~29 nM.
    Mad1 (6-21)
Cat. No. Product Name / Synonyms Application Reactivity